Therapeutic motor training ameliorates cerebellar effects of postnatal binge alcohol

被引:49
作者
Klintsova, AY
Goodlett, CR
Greenough, WT
机构
[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA
[4] Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA
[5] Univ Illinois, Dept Neurosci Program, Urbana, IL 61801 USA
[6] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46204 USA
关键词
alcohol; fetal alcohol effects; motor learning; plasticity; cerebellum;
D O I
10.1016/S0892-0362(99)00052-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have used training on complex motor tasks to ameliorate effect of neonatal alcohol exposure. On postnatal days 4-9, alcohol-exposed (AE) rats were given 4.5 g/kg/day of alcohol by artificial rearing; gastrostomy control (GC) rats were given an isocaloric mixture of maltose/dextrin; suckling control (SC) rats were suckled normally. At 6 months of age, animals from the three groups underwent either rehabilitation training on a series of complex motor tasks, motor conditioning on a fiat runway, or an inactive home cage condition. Subsequently, animals were either tested on three tests of balance and coordination, or were used for cerebellar morphology. After rehabilitation, but not after motor conditioning, male and female AE rats exhibited significant improvement in independent tests of motor skills. Using unbiased stereological morphological techniques, rehabilitated SC and AE animals were found to exhibit significantly more parallel fiber synapses per Purkinje cell in the paramedian lobule. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:125 / 132
页数:8
相关论文
共 63 条
[1]  
Altman J., 1997, DEV CEREBELLAR SYSTE
[2]  
Anderson W J, 1979, Curr Alcohol, V5, P135
[3]  
[Anonymous], ALCOHOL BRAIN DEV
[4]  
BACON F, 1859, WORKS FRANCIS BACON, V2, P664
[5]   EFFECT OF ETHANOL CHRONICALLY ADMINISTERED TO PREWEANLING RATS ON CEREBELLAR DEVELOPMENT - MORPHOLOGICAL-STUDY [J].
BAUERMOFFETT, C ;
ALTMAN, J .
BRAIN RESEARCH, 1977, 119 (02) :249-268
[6]   Prenatal alcohol exposure and the effects of environmental enrichment on hippocampal dendritic spine density [J].
Berman, RF ;
Hannigan, JH ;
Sperry, MA ;
Zajac, CS .
ALCOHOL, 1996, 13 (02) :209-216
[7]  
BERRY M, 1976, BRAIN RES, V119, P249
[8]   LEARNING CAUSES SYNAPTOGENESIS, WHEREAS MOTOR-ACTIVITY CAUSES ANGIOGENESIS, IN CEREBELLAR CORTEX OF ADULT-RATS [J].
BLACK, JE ;
ISAACS, KR ;
ANDERSON, BJ ;
ALCANTARA, AA ;
GREENOUGH, WT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5568-5572
[9]   ALCOHOL-INDUCED NEURONAL LOSS IN DEVELOPING RATS - INCREASED BRAIN-DAMAGE WITH BINGE EXPOSURE [J].
BONTHIUS, DJ ;
WEST, JR .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1990, 14 (01) :107-118
[10]   PERMANENT NEURONAL DEFICITS IN RATS EXPOSED TO ALCOHOL DURING THE BRAIN GROWTH SPURT [J].
BONTHIUS, DJ ;
WEST, JR .
TERATOLOGY, 1991, 44 (02) :147-163