Retinoic Acid Can Directly Promote TGF-β-Mediated Foxp3+ Treg Cell Conversion of Naive T Cells

被引：154

作者：

Mucida, Daniel ^{[3
]}

Pino-Lagos, Karina ^{[1
,2
]}

Kim, Gisen ^{[3
]}

Nowak, Elizabeth ^{[1
,2
]}

Benson, Micah J. ^{[1
,2
]}

Kronenberg, Mitchell ^{[3
]}

Noelle, Randolph J. ^{[1
,2
]}

Cheroutre, Hilde ^{[3
]}

机构：

[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Norris Cotton Canc Ctr, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[3] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA

来源：

IMMUNITY | 2009年 / 30卷 / 04期

关键词：

DIFFERENTIATION; EXPRESSION;

D O I：

10.1016/j.immuni.2009.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：471 / 472

页数：2

共 7 条

[1] All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation [J].

Benson, Micah J. ;

Pino-Lagos, Karina ;

Rosemblatt, Mario ;

Noelle, Randolph J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1765-1774

[2] A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism [J].

Coombes, Janine L. ;

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Sun, Cheng-Ming ;

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Powrie, Fiona .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1757-1764

[3] Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway [J].

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[4] Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells [J].

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[5] Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid [J].

Mucida, Daniel ;

Park, Yunji ;

Kim, Gisen ;

Turovskaya, Olga ;

Scott, Iain ;

Kronenberg, Mitchell ;

Cheroutre, Hilde .

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[6] Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid [J].

Sun, Cheng-Ming ;

Hall, Jason A. ;

Blank, Rebecca B. ;

Bouladoux, Nicolas ;

Oukka, Mohamed ;

Mora, J. Rodrigo ;

Belkaid, Yasmine .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1775-1785

[7] Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression [J].

Xiao, Sheng ;

Jin, Hulin ;

Korn, Thomas ;

Liu, Sue M. ;

Oukka, Mohamed ;

Lim, Bing ;

Kuchroo, Vijay K. .

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