A practical and scaleable preparation of 1,4-anhydroerythritol

被引：14

作者：

Childers, Karla G. ^{[1
]}

Dreher, Spencer D. ^{[1
]}

Lee, Jaemoon ^{[1
]}

Williams, J. Michael ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 05期

关键词：

D O I：

10.1021/op0601058

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical and efficient kilogram-scale preparation of 1,4-anhydroerythritol from meso-erythritol is described. A novel silica gel and sodium bicarbonate slurry/filtration protocol is utilized to purify the product, giving commercial-grade material in 60-65% yield.

引用

页码：934 / 936

页数：3

共 31 条

[1] Nucleosides with furanyl scaffolds [J].

Bera, S ;

Nair, V .

TETRAHEDRON, 2002, 58 (24) :4865-4871

[2] ACID-CATALYZED DEHYDRATION OF ALDITOLS .1. D-GLUCITOL AND D-MANNITOL [J].

BOCK, K ;

PEDERSEN, C ;

THOGERSEN, H .

ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1981, 35 (06) :441-449

[3] SYNTHETIC ROUTES TO TETRAHYDROFURAN, TETRAHYDROPYRAN, AND SPIROKETAL UNITS OF POLYETHER ANTIBIOTICS AND A SURVEY OF SPIROKETALS OF OTHER NATURAL-PRODUCTS [J].

BOIVIN, TLB .

TETRAHEDRON, 1987, 43 (15) :3309-3362

[4] GRAFTING OF POLYESTERS BY FREE-RADICAL CHAIN TRANSFER [J].

BRAUN, D ;

HEMPLER, P .

ANGEWANDTE MAKROMOLEKULARE CHEMIE, 1993, 210 :173-196

[5]

BUCHI G, 1981, J AM CHEM SOC, V103, P3497, DOI 10.1021/ja00402a039

[6] NOVEL CATIONICALLY POLYMERIZABLE PROPENYL AND VINYL ETHERS DERIVED FROM RENEWABLE SOURCES [J].

CRIVELLO, JV ;

BRATSLAVSKY, SA .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1994, 32 (15) :2919-2930

[7]

DUCLOS A, 1994, SYNTHESIS-STUTTGART, P1087

[8] Saturated oxygen heterocycles [J].

Elliott, MC ;

Williams, E .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (19) :2303-2340

[9]

GOTO N, 2004, Patent No. 2004339094

[10]

GOTO N, 2004, Patent No. 2004339093

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