Prevalence of Alleles associated with HIV resistance in Russia

被引：12

作者：

Ryabov, GS

Kazennova, EV

Bobkova, MR

Bobkov, AF

机构：

[1] DI Ivanovskii Inst Virol, Lab T Lymphtrop Viruses, Moscow 123098, Russia

[2] Fed Ctr Aids, Moscow 105275, Russia

来源：

GENETIC TESTING | 2004年 / 8卷 / 01期

关键词：

D O I：

10.1089/109065704323016067

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic polymorphisms of CCR5, CCR2, and SDF1 genes have been associated with resistance during human immunodeficiency virus type 1 (HIV-1) infection and disease progression. In the present report, we studied the frequency and co-occurrence of CCR5Delta32, CCR5-59029A/G, CCR2-64I, and SDF1-3'A allelic variants among HIV-1-seronegative individuals (n = 171) in Moscow. Observed allelic frequencies were 0.0906 [95% confidence interval (CI), 0.06-0.1212] for CCR5Delta32, 0.4072 (95% CI, 0.3542-0.4602) for CCR5-59029G, 0.1061 (95% CI, 0.0728-0.1394) for CCR2-64I, and 0.2218 (95% CI 0.1715-0.2721) for SDF1-3'A. A significant linkage disequilibrium (p = 0.0034) between CCR2-64I and SDF1-39A alleles was observed.

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页码：73 / 76

页数：4

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