Kit and melanocyte migration

被引：47

作者：

Grichnik, James M.

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Dermatol,Melanocyt Dis Sect, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2006年 / 126卷 / 05期

关键词：

D O I：

10.1038/sj.jid.5700164

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

As described in this issue, Alexeev and Yoon introduced a Kit-activating mutation into melanocytes. Although mitogenic in mast cells, this mutation was motogenic in melanocytes. Further, melanocytes had a reduced proliferative rate and were less differentiated. The disparate response may be due to differences in the cellular milieu of melanocytes and may have implications for normal melanocytic integration into the epidermis, nevogenesis, and melanoma.

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页码：945 / 947

页数：3

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