Smoking and the risk of breast cancer among carriers of BRCA mutations

被引：37

作者：

Ghadirian, P

Lubinski, J

Lynch, H

Neuhausen, SL

Weber, B

Isaacs, C

Baruch, RG

Randall, S

Ainsworth, P

Freidman, E

Horsman, D

Tonin, P

Foulkes, WD

Tung, N

Sun, P

Narod, SA

机构：

[1] Univ Toronto, Ctr Res Womens Hlth, Toronto, ON M5G 1N8, Canada

[2] Univ Montreal, CHUM,Fac Med, Hotel Dieu, Fac Med,Epidemiol Res Unit, Montreal, PQ H3C 3J7, Canada

[3] Pomeranian Med Univ, Szczecin, Poland

[4] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE 68178 USA

[5] Univ Calif Irvine, Dept Med, Div Epidemiol, Irvine, CA 92717 USA

[6] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[7] Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

[8] Georgetown Univ, Med Ctr, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA

[9] Rambam Med Ctr, Inst Genet, Haifa, Israel

[10] Univ Toronto, Hlth Network, Dept Obstet & Gynecol, Toronto, ON, Canada

[11] London Reg Canc Ctr, London, ON N6A 4L6, Canada

[12] Chaim Sheba Med Ctr, Oncogenet Unit, IL-52621 Tel Hashomer, Israel

[13] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada

[14] McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ H3A 2T5, Canada

[15] McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ H3A 2T5, Canada

[16] Beth Israel Deaconess Hosp, Boston, MA USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2004年 / 110卷 / 03期

关键词：

BRCA1; BRCA2; smoking; breat cancer;

D O I：

10.1002/ijc.20106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to 1.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations. (C) 2004 Wiley-Liss. Inc.

引用

页码：413 / 416

页数：4

共 21 条

[1] Carcinogenic and endocrine disrupting effects of cigarette smoke and risk of breast cancer [J].