Sarcopenic Obesity and Its Temporal Associations With Changes in Bone Mineral Density, Incident Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project

被引：147

作者：

Scott, David ^{[1
,2
,3
]}

Seibel, Markus ^{[4
,5
]}

Cumming, Robert ^{[6
,7
,8
]}

Naganathan, Vasi

Blyth, Fiona ^{[7
]}

Le Couteur, David G. ^{[7
,9
,10
]}

Handelsman, David J. ^{[9
,11
]}

Waite, Louise M. ^{[7
]}

Hirani, Vasant ^{[7
,12
]}

机构：

[1] Monash Univ, Sch Clin Sci, Monash Hlth, Clayton, Vic 3168, Australia

[2] Univ Melbourne, Melbourne Med Sch, Dept Med, Western Campus, St Albans, Australia

[3] Univ Melbourne, Australian Inst Musculoskeletal Sci, Melbourne Med Sch, Western Campus, St Albans, Australia

[4] Univ Sydney, Concord Hosp, ANZAC Res Inst, Bone Res Program, Sydney, NSW, Australia

[5] Univ Sydney, Concord Hosp, Dept Endocrinol & Metab, Sydney, NSW, Australia

[6] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia

[7] Univ Sydney, Concord Hosp, Ctr Educ & Res Ageing, Sydney, NSW, Australia

[8] Univ Sydney, ARC Ctr Excellence Populat Ageing Res, Sydney, NSW, Australia

[9] Univ Sydney, ANZAC Res Inst, Sydney, NSW, Australia

[10] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia

[11] Univ Sydney, Concord Hosp, Dep Androl, Sydney, NSW, Australia

[12] Univ Sydney, Sch Life & Environm Sci, Charles Perkins Ctr, Sydney, NSW, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2017年 / 32卷 / 03期

基金：

英国医学研究理事会;

关键词：

SARCOPENIA; OBESITY; OSTEOPOROSIS; FALLS; FRACTURE; PHYSICAL PERFORMANCE; DYNAPENIC OBESITY; GAIT SPEED; RISK; COMMUNITY; COHORT; INDIVIDUALS; DISABILITY;

D O I：

10.1002/jbmr.3016

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Body composition and muscle function have important implications for falls and fractures in older adults. We aimed to investigate longitudinal associations between sarcopenic obesity and its components with bone mineral density (BMD) and incident falls and fractures in Australian community-dwelling older men. A total of 1486 men aged >= 70 years from the Concord Health and Ageing in Men Project (CHAMP) study were assessed at baseline (2005-2007), 2-year follow-up (2007-2009; n = 1238), and 5-year follow-up (2010-2013; n = 861). At all three time points, measurements included appendicular lean mass (ALM), body fat percentage and total hip BMD, hand-grip strength, and gait speed. Participants were contacted every 4 months for 6.1 perpendicular to 2.1 years to ascertain incident falls and fractures, the latter being confirmed by radiographic reports. Sarcopenic obesity was defined using sarcopenia algorithms of the European Working Group on Sarcopenia (EWGSOP) and the Foundation for the National Institutes of Health (FNIH) and total body fat >= 30% of total mass. Sarcopenic obese men did not have significantly different total hip BMD over 5 years compared with non-sarcopenic non-obese men (p > 0.05). EWGSOP-defined sarcopenic obesity at baseline was associated with significantly higher 2-year fall rates (incidence rate ratio [ IRR] 1.66; 95% confidence interval [ CI] 1.16-2.37), as were non-sarcopenic obesity (1.30; 1.04-1.62) and sarcopenic non-obesity (1.58; 1.14-2.17), compared with non-sarcopenic non-obese. No association with falls was found for sarcopenic obesity using the FNIH definition (1.01; 0.63-1.60), but after multivariable adjustment, the FNIH-defined nonsarcopenic obese group had a reduced hazard for any 6-year fracture compared with sarcopenic obese men (hazard ratio 0.44; 95% CI 0.23-0.86). In older men, EWGSOP-defined sarcopenic obesity is associated with increased fall rates over 2 years, and FNIH-defined sarcopenic obese men have increased fracture risk over 6 years compared with non-sarcopenic obese men. (C) 2016 American Society for Bone and Mineral Research.

引用

页码：575 / 583

页数：9

共 32 条

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[Anonymous], INT J ENDOCRINOL

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