Engineering novel proteins by transfer of active sites to natural scaffolds

被引：42

作者：

Vita, C

机构：

[1] Commissariat a l'Energie Atomique, Dept. d'Ingenierie d'Etud. Proteines, CE Saclay

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0958-1669(97)80064-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel functional proteins have been generated by the transfer of active sites to structurally homologous proteins and to new structural contexts. The most successful examples of these approaches succeeded in providing effective new tools in biochemistry and protein chemistry and in suggesting new models in drug design.

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收藏

页码：429 / 434

页数：6

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