New 3(2H)-pyridazinone derivatives: Synthesis and affinity towards alpha(1)AR subtypes and 5HT(1A) receptors

被引：8

作者：

Corsano, S

Strappaghetti, G

Leonardi, A

Rhazri, K

Barbaro, R

机构：

[1] UNIV PERUGIA,IST CHIM & TECNOL FARMACO,I-06123 PERUGIA,ITALY

[2] RECORDATI SPA,RICERCA SVILUPPO FARMACEUT,I-20148 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 32卷 / 04期

关键词：

structure-activity relationship; alpha(1) and 5HT(1A) receptor; pyridazinone derivative; arylpiperazine;

D O I：

10.1016/S0223-5234(97)89086-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the evaluation of the radioreceptor binding affinity of a series of 3(2H)-pyridazinone derivatives is reported. Their affinity towards the alpha(1) receptor, three alpha(1)-AR subtype (alpha(1a),alpha(1b),alpha(1d)) receptors and the 5HT(1A) receptor has been determined. The results of the affinity on alpha(1)-AR subtypes and the 5HT(1A)/alpha(1) selectivity are discussed.

引用

页码：339 / 342

页数：4

共 13 条

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BOURDAIS J, 1968, B SOC CHIM FR, V8, P3246

[2]

CORSANO S, 1995, 2 C CHIM PHARM FERR

[3] MOLECULAR-CLONING AND EXPRESSION OF THE CDNA FOR THE HAMSTER ALPHA-1-ADRENERGIC RECEPTOR [J].