Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

被引：146

作者：

Lorenzi, R

Brickell, PM

Katz, DR

Kinnon, C

Thrasher, AJ

机构：

[1] Inst Child Hlth, Dept Mol Immunol, London WC1N 1EH, England

[2] Inst Child Hlth, Dept Mol Haematol, London WC1N 1EH, England

[3] UCL, Sch Med, Dept Immunol, London W1N 8AA, England

来源：

BLOOD | 2000年 / 95卷 / 09期

关键词：

D O I：

10.1182/blood.V95.9.2943.009k17_2943_2946

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Interactions between the Wiskott-Aldrich (WAS) protein (WASp), small GTPases, and the cytoskeletal organizing complex Arp2/3 appear to be critical for the transduction of signals from the cell membrane to the actin cytoskeleton in hematopoietic cells, This study shows that Fc gamma-receptor (Fc gamma R)-mediated phagocytosis is impaired in WASp-deficient peripheral blood monocytes, and that in macrophages, formation of the actin cup and local recruitment of tyrosine phosphorylated proteins is markedly attenuated. Results also show that, in normal macrophages, WASp itself is actively recruited to the cup, suggesting that assembly of this specialized cytoskeletal structure is dependent on its expression. (Blood. 2000;95:2943-2946) (C) 2000 by The American Society of Hematology.

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页码：2943 / 2946

页数：4

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