AUTISM AND IMMUNITY: REVISITED STUDY

被引：23

作者：

Castellani, M. L. ^{[1
]}

Conti, C. M.

Kempuraj, D. J. ^{[3
]}

Salini, V.

Vecchiet, J.

Tete, S. ^{[4
]}

Ciampoli, C. ^{[4
]}

Conti, F. ^{[2
]}

Cerulli, G. ^{[5
]}

Caraffa, A. ^{[5
]}

Antinolfi, P. ^{[5
]}

Galzio, R. ^{[6
]}

Shaik, Y. ^{[7
]}

Theoharides, T. C. ^{[3
]}

De Amicis, D. ^{[11
]}

Perrella, A. ^{[8
]}

Cuccurullo, C. ^{[9
]}

Boscolo, P. ^{[10
]}

Felaco, M. ^{[11
]}

Doyle, R. ^{[12
]}

Verrocchio, C.

Fulcheri, M.

机构：

[1] Univ G dAnnunzio, Dept Med & Aging, Sch Med, Div Immunol, I-66100 Chieti, Italy

[2] Univ G dAnnunzio, Gynecol Div, Chieti, Italy

[3] Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Tufts New England Med Ctr, Boston, MA 02111 USA

[4] Univ G dAnnunzio, Sch Dent, I-66100 Chieti, Italy

[5] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy

[6] Univ Laquila, Neurosurg Unit, Laquila, Italy

[7] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[8] Cotugno Hosp, Dept Infect Dis, Naples, Italy

[9] Univ G DAnnunzio, Atherosclerosis Prevent Ctr, Chieti, Italy

[10] Univ G dAnnunzio, Dept Biomed Sci, Chieti, Italy

[11] Univ G dAnnunzio, Human Dynam Dept, Chieti, Italy

[12] Harvard Univ, Sch Med, Dept Pediat Psychopharmacol, MGH, Boston, MA USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2009年 / 22卷 / 01期

关键词：

NONALLERGIC RHINITIS; GABA-TRANSAMINASE; INFLAMMATION; EXPRESSION; LIVER; MACROPHAGES; INVOLVEMENT; GENES; LIFE;

D O I：

10.1177/039463200902200103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autism spectrum disorder is of interest neurochemically because it represents a relatively homogeneous disorder with regard to disease development, abnormal cognitive development and intellectual development disturbance. A consistent finding in autistic children is a high number of mast cells and a high level of serotonin which is also found at elevated concentrations in the urine of autistic patients. In addition, a dysfunction of clinical conditions, such as gastrointestinal and immunological symptoms, is frequently noted in autistic children, however, IgE does not appear to be prevalent in these children but probably an increase of cytokines/chemokines produced by mast cells at an early age may play an important role. Therefore an immune hypothesis, involving also autoimmunity, is one possible pathogenetic mechanism in autism. In conclusion, mast cell activation could contribute to immune and neuroinflammatory abnormalities that are evident in patients with autism spectrum disorders.

引用

页码：15 / 19

页数：5

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