Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

被引：381

作者：

Altamura, Sandro ^{[1
]}

Muckenthaler, Martina U. ^{[1
]}

机构：

[1] Univ Heidelberg Hosp, Dept Pediat Oncol Haematol & Immunol, Mol Med Partnership Unit, D-69120 Heidelberg, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 16卷 / 04期

关键词：

Alzheimer's disease; atherosclerosis; diseases of aging; iron; iron homeostasis; mouse model; Parkinson's disease; reactive oxygen species; CORONARY-ARTERY-DISEASE; EASTERN FINNISH MEN; RECESSIVE JUVENILE PARKINSONISM; HEMOCHROMATOSIS GENE-MUTATIONS; EARLY EMBRYONIC LETHALITY; LOW-DENSITY-LIPOPROTEIN; CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA-PEPTIDES; TRANSFERRIN C2 ALLELE; SMOOTH-MUSCLE CELLS;

D O I：

10.3233/JAD-2009-1010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Excess free iron generates oxidative stress that hallmarks diseases of aging. The observation that patients with Alzheimer's disease or Parkinson's disease show a dramatic increase in their brain iron content has opened the possibility that disturbances in brain iron homeostasis may contribute to the pathogenesis of these disorders. While the reason for iron accumulation is unknown, iron localization correlates with the production of reactive oxygen species in those areas of the brain that are prone to neurodegeneration. A role for iron is also proposed in atherosclerosis, a further frequent disorder of aging. We will review experimental evidences for an involvement of iron in these diseases and discuss some mouse models with impairment in iron-related genes that may be useful to study the role of iron in these disorders.

引用

页码：879 / 895

页数：17

共 204 条

[1]

GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology [J].