NADPH oxidases and angiotensin II receptor signaling

被引：289

作者：

Garrido, Abel Martin ^{[1
]}

Griendling, Kathy K. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 302卷 / 02期

关键词：

Angiotensin II; NADPH oxidases; Reactive oxygen species; Vascular; Kidney; Brain; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; ELEMENT-BINDING PROTEIN; AKT/PROTEIN KINASE-B; SUPEROXIDE ANION PRODUCTION; TUMOR-SUPPRESSOR PTEN; NAD(P)H OXIDASE; HYDROGEN-PEROXIDE; ANG-II; OXIDATIVE STRESS;

D O I：

10.1016/j.mce.2008.11.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin-angiotensin system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：148 / 158

页数：11

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