Drug transport via the intestinal peptide transporter PepT1

被引：128

作者：

Brandsch, Matthias ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Biozentrum, D-06120 Halle, Germany

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 06期

关键词：

AMINOLEVULINIC-ACID TRANSPORT; PEPT1-MEDIATED TRANSPORT; ORAL ABSORPTION; CANCER-CELLS; PERMEABILITY; RECOGNITION; MECHANISM; INSIGHTS; FAMILY;

D O I：

10.1016/j.coph.2013.08.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The focus of this review is on the pharmaceutical relevance of the intestinal peptide transporter PepT1. The review is limited to the progress made in the field over the past two years. Much of this progress is being driven by the prevailing view that PepT1 can be used for drug delivery purposes. Studies have indeed shown that several drugs, prodrugs and drug candidates gain entry into the systemic circulation via PepT1. Very recent examples are prodrugs of zanamivir, oseltamivir and didanosine.

引用

页码：881 / 887

页数：7

共 35 条

[1]

Proton-Coupled Oligopeptide Transporter (POT) Family Expression in Human Nasal Epithelium and Their Drug Transport Potential [J].

Agu, Remigius ;

Cowley, Elizabeth ;

Shao, Di ;

MacDonald, Christopher ;

Kirkpatrick, David ;

Renton, Ken ;

Massoud, Emad .

MOLECULAR PHARMACEUTICS, 2011, 8 (03) :664-672

[2]

Hijacking Solute Carriers for Proton-Coupled Drug Transport [J].

Anderson, Catriona M. H. ;

Thwaites, David T. .

PHYSIOLOGY, 2010, 25 (06) :364-377

[3]

Pharmaceutical and pharmacological importance of peptide transporters [J].

Brandsch, Matthias ;

Knuetter, Ilka ;

Bosse-Doenecke, Eva .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2008, 60 (05) :543-585

[4]

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls [J].

Brandsch, Matthias .

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2009, 5 (08) :887-905

[5]

Cao F, 2012, ASIAN J PHARM SCI, V7

[6]

Propylene Glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability, and Pharmacokinetics [J].

Cao, Feng ;

Gao, Yahan ;

Wang, Meng ;

Fang, Lei ;

Ping, Qineng .

MOLECULAR PHARMACEUTICS, 2013, 10 (04) :1378-1387

[7]

Ethylene Glycol-Linked Amino Acid Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics [J].

Cao, Feng ;

Jia, Jinghao ;

Yin, Zhi ;

Gao, Yahan ;

Sha, Lei ;

Lai, Yisheng ;

Ping, Qineng ;

Zhang, Yihua .

MOLECULAR PHARMACEUTICS, 2012, 9 (08) :2127-2135

[8]

Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells [J].

Chung, Chung-Wook ;

Kim, Cy Hyun ;

Lee, Hye Myeong ;

Kim, Do Hyung ;

Kwak, Tae-Won ;

Chung, Kyu-Don ;

Jeong, Young-Il ;

Kang, Dae Hwan .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 85 (03) :503-510

[9]

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT [J].

Doki, Shintaro ;

Kato, Hideaki E. ;

Solcan, Nicolae ;

Iwaki, Masayo ;

Koyama, Michio ;

Hattori, Motoyuki ;

Iwase, Norihiko ;

Tsukazaki, Tomoya ;

Sugita, Yuji ;

Kandori, Hideki ;

Newstead, Simon ;

Ishitani, Ryuichiro ;

Nureki, Osamu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (28) :11343-11348

[10]

Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications [J].

Döring, F ;

Walter, J ;

Will, J ;

Föcking, M ;

Boll, M ;

Amasheh, S ;

Clauss, W ;

Daniel, H .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (12) :2761-2767

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