Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold

被引：211

作者：

Cai, Hongli ^{[1
,2
,3
]}

Sharma, Sudhir ^{[2
,3
]}

Liu, Wenying ^{[2
,3
]}

Mu, Wei ^{[2
,3
]}

Liu, Wei ^{[2
,3
]}

Zhang, Xiaodan ^{[2
,3
]}

Deng, Yulin ^{[2
,3
]}

机构：

[1] Jilin Univ, Coll Quartermaster Technol, Changchun 130062, Jilin Province, Peoples R China

[2] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30318 USA

[3] Georgia Inst Technol, IPST Georgia Tech, Atlanta, GA 30318 USA

来源：

BIOMACROMOLECULES | 2014年 / 15卷 / 07期

关键词：

SURFACE-AREA; DELIVERY; CARRIERS; AEROCELLULOSE; ABSORPTION; HYDROXIDE; NANOPAPER; POLYMERS; BULK;

D O I：

10.1021/bm5003976

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We demonstrated that ultralight pure natural aerogel microspheres can be fabricated using cellulose nanofibrials (CNF) directly. Experimentally, the CNF aqueous gel droplets, produced by spraying and atomizing through a steel nozzle, were collected into liquid nitrogen for instant freezing followed by freeze-drying. The aerogel microspheres are highly porous with bulk density as low as 0.0018 g cm(-3). The pore size of the cellulose aeogel microspheres ranges from nano- to macrometers. The unique ultralight and high porous structure ensured high moisture (similar to 90 g g(-1)) and water uptake capacity (similar to 400 g g(-1)) of the aerogel microspheres. Covalent cross-linking between the native nanofibrils and cross-linkers made the aerogel microspheres very stable even in a harsh environment. The present study also confirmed this kind of aerogel microspheres from native cellulose fibers can be used as cell culture scaffold.

引用

页码：2540 / 2547

页数：8

共 45 条

[1]

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