Transcranial magnetic stimulation combined with high-density EEG in altered states of consciousness

被引:40
作者
Napolitani, Martino [1 ]
Bodart, Olivier [2 ,3 ]
Canali, Paola [1 ]
Seregni, Francesca [1 ]
Casali, Adenauer [1 ]
Laureys, Steven [2 ,3 ]
Rosanova, Mario [1 ]
Massimini, Marcello [1 ,4 ]
Gosseries, Olivia [2 ,3 ,5 ,6 ]
机构
[1] Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy
[2] Univ & Univ Hosp Liege, Coma Sci Grp, Cyclotron Res Ctr, Liege, Belgium
[3] Univ & Univ Hosp Liege, Dept Neurol, Liege, Belgium
[4] Fdn Don Carlo Gnocchi, Ist Ricovero Cura Carattere Sci, Milan, Italy
[5] Univ Wisconsin, Dept Psychiat, Ctr Sleep & Consciousness, Madison, WI 53706 USA
[6] Univ Wisconsin, Dept Psychiat & Psychol, Postle Lab, Madison, WI USA
关键词
Consciousness; effective connectivity; electroencephalography; minimally conscious state; transcranial magnetic stimulation; unresponsive wakefulness syndrome; vegetative state; CORTICAL EFFECTIVE CONNECTIVITY; VEGETATIVE STATE; COGNITIVE NEUROSCIENCE; WAKEFULNESS SYNDROME; BISPECTRAL INDEX; BRAIN ACTIVITY; COMBINED TMS; DISORDERS; EXCITABILITY; RESPONSES;
D O I
10.3109/02699052.2014.920524
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Background: This review discusses the advantages of transcranial magnetic stimulation combined with high-density electroencephalography (TMS-hdEEG) over other current techniques of brain imaging. Methods and results: Its application was reviewed, focusing particularly on disorders of consciousness, in the perspective of recent theories of consciousness. Assessment of non-communicative patients with disorders of consciousness remains a clinical challenge and objective measures of the level of consciousness are still needed. Current theories suggest that a key requirement for consciousness is the brain's capacity to rapidly integrate information across different specialized cortical areas. TMS-EEG allows the stimulation of any given cortical area and the recording of the immediate electrical cortical response. This technique has recently been successfully employed to measure changes in brain complexity under physiological, pharmacological and pathological conditions. Conclusions: This suggests that TMS-EEG is a reliable tool to discriminate between conscious and unconscious patients at the single subject level. Future works are needed to validate and implement this technique as a clinical tool.
引用
收藏
页码:1180 / 1189
页数:10
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