Comparative analysis of anti-hepatitis C virus activity and gene expression mediated by alpha, beta, and gamma interferons

被引：69

作者：

Cheney, IW ^{[1
]}

Lai, VCH ^{[1
]}

Zhong, WD ^{[1
]}

Brodhag, T ^{[1
]}

Dempsey, S ^{[1
]}

Lim, C ^{[1
]}

Hong, Z ^{[1
]}

Lau, JYN ^{[1
]}

Tam, RC ^{[1
]}

机构：

[1] Ribapharm Inc, Costa Mesa, CA 92626 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 21期

关键词：

D O I：

10.1128/JVI.76.21.11148-11154.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-gamma and IFN-alpha/beta with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.

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页码：11148 / 11154

页数：7

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