Identification of an oculomotor biomarker of preclinical Huntington disease

被引：65

作者：

Golding, C. V. P.

Danchaivijitr, C.

Hodgson, T. L.

Tabrizi, S. J.

Kennard, C.

机构：

[1] Univ Exeter, Imperial Coll, Dept Clin Neurosci, Fac Med,Sch Psychol, London W6 8RP, England

[2] Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England

[3] Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England

来源：

NEUROLOGY | 2006年 / 67卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1212/01.wnl.0000218215.43328.88

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.

引用

页码：485 / 487

页数：3

共 10 条

[1]

Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington's disease [J].