Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells

被引：29

作者：

Yang, Haijun ^{[1
]}

Zhang, Ning ^{[1
]}

Li, Xiang ^{[1
]}

Chen, Jianwei ^{[1
]}

Cai, Baochang ^{[2
]}

机构：

[1] Nanjing Univ Chinese Med, Dept Pharm, Nanjing 210046, Peoples R China

[2] Nanjing Univ Chinese Med, Key Proc Lab Jangsu, Nanjing 210046, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 08期

关键词：

Annonace; Annonaceous acetogenins; Structure-activity relationship; Cytotoxicities; MITOCHONDRIAL COMPLEX-I; POTENT INHIBITORS; BULLATACIN; ANTITUMOR; ANALOGS; MODE;

D O I：

10.1016/j.bmcl.2009.02.105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twelve annonaceous acetogenins (ACGs) with different stereochemical structures and configuration were selected to test for their inhibitions on the growth of Hela, SMMC-7541, SGC-7901, MCF-7 and A-5408 tumor cell lines using MTT method. This was the first to simultaneously investigate effects of structural factors of stereochemical structures and configuration on cytotoxicities with structure-activity relationship. The present study showed that cytotoxic selectivities of ACGs with threo/trans/threo/trans/erythro stereochemical arrangement were gently more active than those with threo/trans/threo/trans/threo stereochemical arrangement, and ACGs with cis THF ring partly produced notable cytotoxic selectivities. Furthermore, ACGs with S configuration at C-24 exhibited gently more cytotoxic selectivities potency than those with R configuration at C-24. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2199 / 2202

页数：4

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