Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia

被引:48
作者
Balasubramanian, Priya [1 ]
DelFavero, Jordan [1 ]
Ungvari, Anna [1 ]
Papp, Magor [2 ]
Tarantini, Amber [1 ,2 ,3 ]
Price, Nathan [4 ]
de Cabo, Rafael [4 ]
Tarantini, Stefano [1 ,2 ,5 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,Ctr Gerosci & Hlth Brain, Vasc Cognit Impairment & Neurodegenerat Program,R, Oklahoma City, OK 73190 USA
[2] Semmelweis Univ, Int Training Program Gerosci, Doctoral Sch Basic & Translat Med, Dept Publ Hlth, Budapest, Hungary
[3] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK USA
[4] NIA, Translat Gerontol Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA
[5] Univ Oklahoma, Hlth Sci Ctr, Dept Hlth Promot Sci, Coll Publ Hlth, Oklahoma City, OK USA
关键词
Time restricted feeding; Aging; Neurovascular coupling; Neurodegeneration geroscience; Dementia; Cognitive function; INDUCED CEREBRAL MICROHEMORRHAGES; DISEASE RISK MARKERS; CALORIC RESTRICTION; OXIDATIVE STRESS; ENERGY RESTRICTION; NITRIC-OXIDE; DIETARY RESTRICTION; WEIGHT-LOSS; AUTOREGULATORY DYSFUNCTION; ENDOTHELIAL IMPAIRMENT;
D O I
10.1016/j.arr.2020.101189
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the number of individuals affected by VCI is expected to exponentially increase in the upcoming decades. Yet, there are no current preventative or therapeutic treatments available against the development and progression of VCI. Therefore, there is a pressing need to better understand the pathophysiology underlying these conditions, for the development of novel tools and interventions to improve cerebrovascular health and delay the onset of VCI. There is strong epidemiological and experimental evidence that lifestyle factors, including nutrition and dietary habits, significantly affect cerebrovascular health and thereby influence the pathogenesis of VCI. Here, recent evidence is presented discussing the effects of lifestyle interventions against age-related diseases which in turn, inspired novel research aimed at investigating the possible beneficial effects of dietary interventions for the prevention of cognitive decline in older adults.
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收藏
页数:9
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