Palladium-catalyzed alkylation of sp2 and sp3 C-H bonds with methylboroxine and alkylboronic acids:: Two distinct C-H activation pathways

被引：483

作者：

Chen, Xiao ^{[1
]}

Goodhue, Charles E. ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem MS015, Waltham, MA 02454 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 39期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/ja0646747

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium-catalyzed alkylations of sp2 and sp3 C-H bonds with either methylboroxine or alkylboronic acids were developed. Ag2O or AgCO3 is used as a crucial oxidant and promoter for the transmetalation step. Ether, ester, alcohol, and alkene functional groups are tolerated. A new C-H activation pathway differing from the cyclometalation process is elucidated using methylboroxine as the coupling partner. Copyright © 2006 American Chemical Society.

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页码：12634 / 12635

页数：2

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