A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF)

被引:120
作者
Abe, Yasunori
Wada, Hideo
Tomatsu, Hiroaki
Sakaguchi, Akane
Nishioka, Junji
Yabu, Yasunori
Onishi, Katsuya
Nakatani, Kaname
Morishita, Yoshitaka
Oguni, Shinichiro
Nobori, Tsutomu
机构
[1] Mie Univ, Sch Med, Dept Lab Med, Tsu, Mie 5148507, Japan
[2] Mie Univ Hosp, Cent Clin Labs, Tsu, Mie, Japan
[3] Sysmex Corp, Prod Dev, Kobe, Hyogo, Japan
关键词
IPF (immature platelet fraction); reticulated platelet; ITP (idiopathic thrombocytopenic purpura); AA (aplastic anemia);
D O I
10.1016/j.thromres.2005.09.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Immature platelet fraction (IPF) has been measured by fully automated analyzer (XE-2100) as reticulated platelet (RP) which is reflected with thrombopoiesis in bone marrow. IPF value in the healthy volunteers was 3.3% (1.0-10.3) and upper 95% confidential interval (95% Cl) of IPF was determined as 7.7%. IPF was significantly high in the patients with idiopathic thrombocytopenic purpura (ITP; 17.4%, 1.2-53.2%) and recovery phase of post-chemotherapy, and significantly low in nadir phase of post-chemotherapy, and within normal range in the patients with ITP in complete remission (CR) and with aplastic anemia (AA). Total count of IPF was significantly tow in patients with ITP, AA or post-chemotherapy. Mean platelet volume (MPV) was significantly high in only patients with ITP. IPF 7.7% is best point for highest sensitivity (86.8%) and specificity (92.6%) in diagnosis of ITP and recovery phase of post-chemotherapy. In receiver operating characteristic curve for diagnosis of ITP and recovery phase of post-chemotherapy, IPF was significantly more useful than MPV. These results show that IPF reflects the pathology of thrombocytopenic disorders, and that measurement of IPF is useful for the differential diagnosis and analysis of platelet kinetics. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:463 / 469
页数:7
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