Solubility enhancement of glibenclamide in choline-tryptophan ionic liquid: Preparation, characterization and mechanism of solubilization

被引：37

作者：

Alawi, Mahmoud A. ^{[1
]}

Harridan, Imad I. ^{[2
]}

Sallam, ALSayed A. ^{[3
]}

Abu Heshmeh, Najiah ^{[1
]}

机构：

[1] Univ Jordan, Dept Chem, Amman 11942, Jordan

[2] Univ Jordan, Fac Pharm, Amman 11942, Jordan

[3] TQ Pharma, Amman, Jordan

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2015年 / 212卷

关键词：

Choline; Tryptophan; Ionic liquid; Solubility; Glibenclamide; DISSOLUTION; NMR;

D O I：

10.1016/j.molliq.2015.10.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

A new ionic liquid solvent was prepared from choline as a cation and tryptophan as the anion. The produced ionic liquid was characterized by NMR, UV and HPLC. The obtained solvent was shown to form in a ratio of 1:1 (choline: tryptophan). The produced solvent was shown to increase the solubility of the low water solubility drug glibenclamide. The mechanism of the observed solubility enhancing effect of the drug was investigated and it did not seem to be simply due to increase in the pH of the medium. The most likely mechanism of increase in the solubility of glibenclamide (Glib) is the formation of complex hydrogen bonds and pi-pi interaction of the aromatic rings. (c) 2015 Elsevier B.V. All rights reserved.

引用

页码：629 / 634

页数：6

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