MicroRNAs Expression and Function in Cerebral Ischemia Reperfusion Injury

被引：175

作者：

Yu Di ^{[1
]}

Yang Lei ^{[1
]}

Feng Yu ^{[1
]}

Fan Changfeng ^{[1
]}

Wang Song ^{[1
]}

Mo Xuming ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Childrens Hosp, Dept Cardiothorac Surg, Nanjing 210008, Jiangsu, Peoples R China

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2014年 / 53卷 / 02期

关键词：

Cerebral; Ischemia reperfusion injury; MicroRNAs; TRANSIENT FOCAL ISCHEMIA; PROTEIN EXPRESSION; CELL-DEATH; BRAIN; APOPTOSIS; NEURONS; TARGETS; CANCER; DISEASE;

D O I：

10.1007/s12031-014-0293-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRNAs) are small (18 similar to 25 nt) noncoding single-stranded RNA molecules that act as negative regulators of gene expression and modulating the stability and/or the translational efficiency of target messenger RNAs. Studies have shown that miRNAs control diverse aspects of brain disease. Recently, several studies have suggested that miRNAs alter the response to ischemia reperfusion injury and regulate the expression of various key elements in cell survival and apoptosis. This review article gives a brief overview of some miRNAs (miR-15a/b, miR-21, miR-29b/c, miR-124, miR-145, miR-181, miR-200 family, miR-338, miR-422a, miR-497, and miR let 7 family) in cerebral ischemia reperfusion injury. Although miRNAs could be potential therapeutic targets for the treatment of ischemia reperfusion injury, their safety and other limitations need further confirmation.

引用

页码：242 / 250

页数：9

共 58 条

[1]

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