Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson disease

被引：108

作者：

Mesnage, V

Houeto, JL

Bonnet, AM

Clavier, I

Arnulf, I

Cattelin, F

Le Fur, G

Damier, P

Welter, ML

Agid, Y

机构：

[1] Hop La Pitie Salpetriere, Ctr Invest Clin, INSERM, U289, F-75013 Paris, France

[2] Sanofi Synthelabo, Paris, France

[3] Hop Laennec, Neurol Serv, Nantes, France

来源：

CLINICAL NEUROPHARMACOLOGY | 2004年 / 27卷 / 03期

关键词：

Parkinson disease; peptides; dopaminergic transmission;

D O I：

10.1097/00002826-200405000-00003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neuropeptides neurokinin 13, neurotensin, and anandamide, the endogenous ligands of NK3, NT1, and CB1 receptors respectively, are known to interact with brain dopaminergic transmission. This study evaluated the effects of these three antagonists of the NK3, (SR 142801), neurotensin (SR 48692), and cannabinoid (SR 141716) receptors on the severity of motor symptoms and levodopa-induced dyskinesias after administration of a single dose of levodopa in 24 patients with Parkinson disease. In this exploratory randomized, double-blind, placebo-controlled study, at the dose used, the drugs tested were well tolerated and could not improve parkinsonian motor disability.

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页码：108 / 110

页数：3

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