Review article:: gastric cancer and Helicobacter pylori

被引:28
作者
Axon, A [1 ]
机构
[1] Gen InfirmLeeds, Dept Gastroenterol, Leeds LS1 3EX, W Yorkshire, England
关键词
D O I
10.1046/j.1365-2036.16.s4.14.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gastric cancer is the second commonest cause of death from malignancy in the world. Its pathogenesis is comparatively well understood and its aetiology multi-factorial. Non-cardia gastric cancer usually arises in a stomach that has been inflamed over a long period and where atrophy and intestinal metaplasia have supervened. The commonest cause of gastric inflammation is infection with Helicobacter pylori. Colonization with this organism increases the relative risk of developing this cancer by about six [Helicobacter and Cancer Collaborative Group. Gut 2001; 49: 347-53]. Its likelihood increases with the severity and extent of the gastritis. Severity is influenced by the virulence of the infecting organism, the genetics of the host, bile reflux, dietary factors and the presence of hypochlorhydria which influences the extent, as well as the severity, of the inflammation. The only predisposing factor which can easily be manipulated is H. pylori infection, which can be successfully treated in 80-90% of cases using a 1-week therapeutic regimen.
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页码:83 / 88
页数:6
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