Identification and localization of glycine in the inner core lipopolysaccharide of Neisseria meningitidis

被引：20

作者：

Cox, AD ^{[1
]}

Li, JJ ^{[1
]}

Richards, JC ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2002年 / 269卷 / 17期

关键词：

Neisseria meningitidis; lipopolysaccharide; glycine; NMR; mass spectrometry;

D O I：

10.1046/j.1432-1033.2002.03131.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amino acid glycine is identified as a component of the inner core oligosaccharide in meningococcal lipopolysaccharide (LPS). Ester-linked glycine residues were consistently found by mass spectrometry experiments to be located on the distal heptose residue (HepII) in LPS from several strains of Neisseria meningitidis. Nuclear magnetic resonance studies confirmed and extended this observation locating the glycine residue at the 7-position of the HepII molecule in L3 and L4 immunotype strains.

引用

页码：4169 / 4175

页数：7

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