Tuning inflammation and immunity by chemokine sequestration: decoys and more

被引：407

作者：

Mantovani, Alberto

Bonecchi, Raffaella

Locati, Massimo

机构：

[1] Ist Clin Humanitas, I-20089 Milan, Italy

[2] Univ Milan, Ist Patol Gen, I-20133 Milan, Italy

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 12期

关键词：

D O I：

10.1038/nri1964

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.

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收藏

页码：907 / 918

页数：12

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