Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

被引：110

作者：

Berglund, Eric D. ^{[1
]}

Liu, Tiemin ^{[1
]}

Kong, Xingxing ^{[2
,3
]}

Sohn, Jong-Woo ^{[4
]}

Vong, Linh ^{[2
,3
]}

Deng, Zhuo ^{[5
]}

Lee, Charlotte E. ^{[1
]}

Lee, Syann ^{[1
]}

Williams, Kevin W. ^{[1
]}

Olson, David P. ^{[6
]}

Scherer, Philipp E. ^{[7
]}

Lowell, Bradford B. ^{[2
,3
]}

Elmquist, Joel K. ^{[1
,8
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Korea Adv Inst Sci & Technol, Dept Sci Biol, Taejon 305701, South Korea

[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Sch Med, Dept Obstet & Gynecol, Xian 710049, Peoples R China

[6] Univ Michigan, Dept Pediat, Div Endocrinol, Ann Arbor, MI 48109 USA

[7] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA

[8] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

BROWN ADIPOSE-TISSUE; ADAPTIVE THERMOGENESIS; GLUCOSE-HOMEOSTASIS; OBESITY; ACTIVATION; CIRCUITRY; RESPONSES; HUMANS; MICE;

D O I：

10.1038/nn.3737

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.

引用

页码：911 / 913

页数：3

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