Crosstalk between histone modifications during the DNA damage response

被引：429

作者：

van Attikum, Haico ^{[1
]}

Gasser, Susan M. ^{[2
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Toxicogenet, NL-2333 ZC Leiden, Netherlands

[2] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2009年 / 19卷 / 05期

关键词：

DOUBLE-STRAND BREAKS; CHROMATIN REMODELING COMPLEX; GENOMIC STABILITY; HOMOLOGOUS RECOMBINATION; H2AX PHOSPHORYLATION; MDC1; INO80; CHECKPOINT; GAMMA-H2AX; REPAIR;

D O I：

10.1016/j.tcb.2009.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromatin structure has a crucial role in processes of metabolism, including transcription, DNA replication and DNA damage repair. An evolutionarily conserved variant of histone H2A, called H2AX, is one of the key components of chromatin. H2AX becomes rapidly phosphorylated on chromatin surrounding DNA double-strand breaks (DSBs). Recent studies have shown that H2AX and other components of damaged chromatin also become modified by acetylation and ubiquitylation. This review discusses how specific combinations of histone modifications affect the accumulation and function of DNA repair factors (MDC1, RNF8, RNF168, 53BP1, BRCA1) and chromatin remodeling complexes (INO80, SWR1, TIP60-p400) at DSBs. These collectively regulate DSB repair and checkpoint arrest, avoiding genomic instability and oncogenic transformation in higher eukaryotes.

引用

页码：207 / 217

页数：11

共 88 条

[1] Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1 [J].

Bekker-Jensen, S ;

Lukas, C ;

Melander, F ;

Bartek, J ;

Lukas, J .

JOURNAL OF CELL BIOLOGY, 2005, 170 (02) :201-211

[2] Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage [J].

Bin Wang ;

Elledge, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (52) :20759-20763

[3] Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair [J].

Bird, AW ;

Yu, DY ;

Pray-Grant, MG ;

Qiu, QF ;

Harmon, KE ;

Megee, PC ;

Grant, PA ;

Smith, MM ;

Christman, MF .

NATURE, 2002, 419 (6905) :411-415

[4] Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair [J].

Botuyan, Maria Victoria ;

Lee, Joseph ;

Ward, Irene M. ;

Kim, Ja-Eun ;

Thompson, James R. ;

Chen, Junjie ;

Mer, Georges .

CELL, 2006, 127 (07) :1361-1373

[5] Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks [J].

Celeste, A ;

Fernandez-Capetillo, O ;

Kruhlak, MJ ;

Pilch, DR ;

Staudt, DW ;

Lee, A ;

Bonner, RF ;

Bonner, WM ;

Nussenzweig, A .

NATURE CELL BIOLOGY, 2003, 5 (07) :675-U51

[6] Genomic instability in mice lacking histone H2AX [J].

Celeste, A ;

Petersen, S ;

Romanienko, PJ ;

Fernandez-Capetillo, O ;

Chen, HT ;

Sedelnikova, OA ;

Reina-San-Martin, B ;

Coppola, V ;

Meffre, E ;

Difilippantonio, MJ ;

Redon, C ;

Pilch, DR ;

Olaru, A ;

Eckhaus, M ;

Camerini-Otero, RD ;

Tessarollo, L ;

Livak, F ;

Manova, K ;

Bonner, WM ;

Nussenzweig, MC ;

Nussenzweig, A .

SCIENCE, 2002, 296 (5569) :922-927

[7] H2AX haploinsufficiency modifies genomic stability and tumor susceptibility [J].

Celeste, A ;

Difilippantonio, S ;

Difilippantonio, MJ ;

Fernandez-Capetillo, O ;

Pilch, DR ;

Sedelnikova, OA ;

Eckhaus, M ;

Ried, T ;

Bonner, WM ;

Nussenzweig, A .

CELL, 2003, 114 (03) :371-383

[8] Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage [J].

Chapman, J. Ross ;

Jackson, Stephen P. .

EMBO REPORTS, 2008, 9 (08) :795-801

[9] ATR: an essential regulator of genome integrity [J].

Cimprich, Karlene A. ;

Cortez, David .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (08) :616-627

[10] γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation [J].

Cowell, Ian G. ;

Sunter, Nicola J. ;

Singh, Prim B. ;

Austin, Caroline A. ;

Durkacz, Barbara W. ;

Tilby, Michael J. .

PLOS ONE, 2007, 2 (10)

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