Combinatorial protein reagents to manipulate protein function

被引：41

作者：

Colas, P ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, Biol Cellulaire & Mol Lab, F-69364 Lyon 07, France

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(99)00051-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The design and use of combinatorial protein libraries has become a fast moving field in molecular biology. Different experimental systems supporting various selection schemes are now available. The latest breakthroughs include evolutionary experiments to improve existing binding surfaces, selections of homodimerizing peptides, the use of peptide aptamers to disrupt protein interactions inside living cells, and functional selections of aptamers to probe regulatory networks.

引用

页码：54 / 59

页数：6

共 45 条

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