Bridging Physiology and Pathology in AD

被引：73

作者：

Kim, Dohoon ^{[1
]}

Tsai, Li-Huei ^{[1
,2
,3
]}

机构：

[1] MIT Picower Inst Learning & Memory, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[2] MIT, Stanley Ctr Psychiat Res, Broad Inst, Cambridge, MA 02142 USA

[3] Harvard Univ, Cambridge, MA 02142 USA

来源：

CELL | 2009年 / 137卷 / 06期

关键词：

AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; CELL-DEATH;

D O I：

10.1016/j.cell.2009.05.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and A beta 42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.

引用

页码：997 / 1000

页数：4

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