Cadherin expression in ovarian carcinoma and malignant mesothelioma cell effusions

被引：22

作者：

Sivertsen, Stine

Berner, Aasmund

Michael, Claire W.

Bedrossian, Carlos

Davidson, Ben ^{[1
]}

机构：

[1] Univ Oslo, Dept Pathol, Norwegian Radium Hosp, Natl Hosp, N-0310 Oslo, Norway

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Norwegian Amer Hosp, Chicago, IL USA

来源：

ACTA CYTOLOGICA | 2006年 / 50卷 / 06期

关键词：

cadherins; carcinoma; ovarian; primary peritoneal; mesothelioma;

D O I：

10.1159/000326027

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective To analyze potential differences in cadherin expression between ovarian carcinoma/primary peritoneal carcinoma (OC/PPC) and malignant mesothelioma (MM) at this anatomic site. Study Design MM (N = 24) and OC/PPC (N = 53) effiisions were analyzed for E-cadherin, N-cadberin and P-cadherin protein expression using immunocytochemistry. Results Both MM and OC/PPC cells showed frequent expression of all 3 cadherins. OC/PPC specimens expressed E-cadherin and N-cadherin in 52 of 53 cases and P-cadherin in 51 of 53 cases. MM effusions expressed E-cadherin, N-cadherin and P-cadherin in 22 of 24, 21 of 24 and 23 of 24 cases, respectively. The differences in the percentage of cadherin-positive cells was weakly Significant for P-cadherin (higher expression in MM, p = 0.04), but E-cadherin and N-cadherin expression was comparable (p > 0.05). Conclusion MM and OC/PPC coexpress different cadherin family members. P-cadherin, E-cadherin and N-cadherin are not useful for differentiation between OC/PPC and MM in effusions.

引用

页码：603 / 607

页数：5

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