A very short route to enantiomerically pure coumarin-bearing fluorescent amino acids

被引：113

作者：

Brun, MP

Bischoff, L

Garbay, C

机构：

[1] Univ Paris 05, UFR Biomed, CNRS, FRE 2718,INSERM,U648,Lab Pharmacochim Mol & Cellu, F-75270 Paris 06, France

[2] INSA, UPRESA 6014, IRCOF, F-76131 Mont St Aignan, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 26期

关键词：

amino acids; coumarin; cyclization; fluorescent probes; solid-phase synthesis;

D O I：

10.1002/anie.200454116

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

No bulkier than a tryptophan or a tyrosine residue are the fluorescent coumaryl amino acids described. These building blocks can be synthesized rapidly with high enantiomeric purity and introduced readily into a peptidic sequence. Their fluorescence properties allow, for example, the investigation of the cellular localization of labeled peptides through confocal fluorescence microscopy (see picture).

引用

页码：3432 / 3436

页数：5

共 37 条

[1] The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls [J].