CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: Fermentation, isolation, structural elucidation and biological activities

被引：59

作者：

Dekker, KA

Inagaki, T

Gootz, TD

Kaneda, K

Nomura, E

Sakakibara, T

Sakemi, S

Sugie, Y

Yamauchi, Y

Yoshikawa, N

Kojima, N

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

[2] PFIZER PHARMACEUT INC,DIV CENT RES,AICHI 47023,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 10期

关键词：

D O I：

10.7164/antibiotics.50.833

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387. The two most potent phthalide compounds, CJ-12,954 and CJ-I3,014, have MICs of 5 ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.

引用

页码：833 / 839

页数：7

共 17 条

[1] SECONDARY MOLD METABOLITES .27. PHANEROSPORIC ACID, A BETA-RESORCYLATE OBTAINED FROM PHANEROCHAETE-CHRYSOSPORIUM [J].