A model of accelerated aging induced by 5-bromodeoxyuridine

被引：6

作者：

Butov, AA

Volkov, MA

Anisimov, VN

Sehl, ME

Yashin, AI

机构：

[1] Max Planck Inst Demog Res, Lab Adv Stat Methods, D-18057 Rostock, Germany

[2] Ulyanovsk State Univ, Fac Mech & Math, Dept Appl Math, Ulyanovsk 432700, Russia

[3] NN Petrov Oncol Res Inst, Lab Carcinogenesis & Aging, St Petersburg 197758, Russia

[4] Brown Univ, Sch Med, Div Biol & Med, Providence, RI 02912 USA

来源：

BIOGERONTOLOGY | 2002年 / 3卷 / 03期

关键词：

accelerated aging; aging; carcinogenesis; genetics of aging; mutagenesis; processes; random; semimartingale methods; simulation; 5-bromodeoxyuridine;

D O I：

10.1023/A:1015647225196

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

We consider a scheme of aging with two possible mechanisms of senescence processes: aging with apoptosis and necrosis for differentiated cells and a multistage process of malignant transformation. Our model describes the multistage phenomena of aging and carcinogenesis by a set of stochastic equations using multivariate and diffusion processes. This model fits experimental data on the acceleration of aging processes from postnatal exposure to 5-bromodeoxyuridine (BrdU), and the induction of genome instability. The methods of stochastic modeling and computer simulation of the processes of aging and carcinogenesis have been used for the verification of the biological suggestions.

引用

页码：175 / 182

页数：8

共 22 条

[1]

CARCINOGENESIS INDUCED BY NEONATAL EXPOSURE TO VARIOUS DOSES OF 5-BROMO-2'-DEOXYURIDINE IN RATS [J].