Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution

被引：67

作者：

Tremblay, A ^{[1
]}

Pelletier, C

Doucet, E

Imbeault, P

机构：

[1] Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Fac Med, St Foy, PQ G1K 7P4, Canada

[2] Univ Ottawa, Sch Human Kinet, Ottawa, ON K1N 6N5, Canada

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2004年 / 28卷 / 07期

关键词：

adaptive thermogenesis; organochlorine; leptin; weight loss;

D O I：

10.1038/sj.ijo.0802527

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The main objective of this study was to investigate the potential impact of body organochlorine (OC) pollution on the adaptive change in thermogenesis induced by body weight loss. Fat mass (FM), fat-free mass (FFM), and sleeping metabolic rate (SMR) were measured in obese individuals before and after a weight-reducing program. The measured values of SMR were then compared to those predicted from a reference equation established from FM and FFM in control subjects. Plasma OC, leptin, total tri-iodothyronine, and free thyroxine concentrations were also measured in obese subjects before and after weight loss. After weight loss, the measured decrease in SMR was greater than that predicted by changes in FM and FFM. Increased plasma OC concentration was the factor explaining the greatest proportion of the difference between predicted and measured SMR changes induced by body weight loss. OC pollution seems to be a new factor affecting the control of thermogenesis in some obese individuals experiencing body weight loss.

引用

收藏

页码：936 / 939

页数：4

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