Micro- and nanofluidic systems for high-throughput biological screening

被引：154

作者：

Hong, Jongin ^{[1
,2
]}

Edel, Joshua B. ^{[1
,2
]}

deMello, Andrew J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, London SW7 2AZ, England

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 3-4期

基金：

英国工程与自然科学研究理事会;

关键词：

DIP-PEN NANOLITHOGRAPHY; CELL-CULTURE ARRAY; MODE WAVE-GUIDES; ON-A-CHIP; SINGLE-MOLECULE SPECTROSCOPY; LARGE-SCALE INTEGRATION; DRUG DISCOVERY; SOFT LITHOGRAPHY; DROPLET MICROFLUIDICS; PROTEIN EXPRESSION;

D O I：

10.1016/j.drudis.2008.10.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High-throughput screening (HTS) is a method of scientific experimentation widely used in drug discovery and relevant to the fields Of biology. The development of micro- and nanofluidic systems for use in the biological sciences has been driven by a range of fundamental attributes that accompany miniaturization and massively parallel experimentation. We review recent advances in both arraying strategies based on nano/microfluidics and novel nano/microfluidic devices with high analytical throughput rates.

引用

页码：134 / 146

页数：13

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