No evidence of chikungunya virus and antibodies shortly before the outbreak on Sri Lanka

被引：7

作者：

Panning, Marcus ^{[2
]}

Wichmann, Dominic ^{[2
]}

Grywna, Klaus ^{[2
]}

Annan, Augustina ^{[2
]}

Wijesinghe, Sriyal ^{[3
]}

Kularatne, S. A. M. ^{[3
]}

Drosten, Christian ^{[1
]}

机构：

[1] Univ Bonn, Med Ctr, Inst Virol, D-53127 Bonn, Germany

[2] Bernhard Nocht Inst Trop Med, Hamburg, Germany

[3] Univ Peradeniya, Dept Med, Kandy, Sri Lanka

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2009年 / 198卷 / 02期

关键词：

Chikungunya; Antibodies; Dengue; RT-PCR; REUNION ISLAND; ADULT PATIENTS; DENGUE; FEVER; LIVE; DISAPPEARANCE; ARBOVIRUSES; EPIDEMIC; MOSQUITO; VACCINE;

D O I：

10.1007/s00430-009-0110-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A massive outbreak of chikungunya disease occurred on Sri Lanka in 2006. Reasons for the explosive nature of the epidemic are being intensively discussed. According to recognised and anecdotal concepts, absence of human population immunity against chikungunya virus (CHIKV) might have supported virus amplification. However, formal proof of concept is lacking. This study determined the prevalence of anti-CHIKV IgG antibodies as well as CHIKV RNA shortly before the outbreak. Two hundred and six human sera were collected from patients with acute febrile illness in 2004/2005. Validated indirect immunofluorescence and real-time RT-PCR assays for dengue as well as CHIKV were employed. Laboratory evidence of dengue virus infection was seen in 67% of patients, indicating virus activity and exposure to Aedes spp. vectors. These vectors are the same as for chikungunya. However, no evidence of acute or previous chikungunya infection could be demonstrated in the same cohort. This study gives formal evidence that the absence of human population immunity correlated with a large chikungunya epidemic.

引用

页码：103 / 106

页数：4

共 24 条

[1] Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemic [J].