Adsorption of fluoxetine HCl by activated charcoal

被引：9

作者：

Cooney, DO

Thomason, R

机构：

[1] Department of Chemical Engineering, University of Wyoming, Laramie

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1997年 / 86卷 / 05期

关键词：

D O I：

10.1021/js960418o

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5). The data were fitted to both Langmuir and Freundlich equations. The Langmuir Q(m) values (maximal adsorption capacities) for pH 1.2 and 7.5 were 0.258 and 0.330 g drug/g charcoal, respectively. These excellent capacities suggest that oral charcoal therapy would be effective for fluoxetine overdose.

引用

页码：642 / 644

页数：3

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