Analysis of dichloroacetic acid in drinking water by ion exchange HILIC-LC/MS/MS

被引：23

作者：

Dixon, AM

Delinsky, DC

Bruckner, JV

Fisher, JW

Bartlett, MG ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

[2] Univ Georgia, Coll Agr & Environm Sci, Dept Environm Hlth, Athens, GA 30602 USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2004年 / 27卷 / 15期

关键词：

dichloroacetic acid; HILIC; ion exchange; drinking water;

D O I：

10.1081/JLC-200028136

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dichloroacetic acid (DCA) is a small, polar compound that individuals are exposed to as a result of drinking water consumption. The occurrence of DCA in drinking water is of concern because DCA has been shown to cause cancer in laboratory animals. To date, no validated LC/MS/MS methods are available for quantitative analysis of DCA. In addition, most methods use a derivatizing reagent that can artificially inflate the levels of DCA. Presented in this paper, is a validated LC/MS/MS method for the analysis of DCA in drinking water. An amino column was used with ion-exchange hydrophilic interaction chromatography (HILIC).

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收藏

页码：2343 / 2355

页数：13

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