A novel TNF-inducible message with putative growth suppressor function

被引：1

作者：

Nadadur, SS ^{[1
]}

Ehrke, MJ ^{[1
]}

Gurtoo, HL ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Grace Canc Drug Ctr, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1489卷 / 2-3期

关键词：

TNF; induction; mRNA; growth; suppression;

D O I：

10.1016/S0167-4781(99)00189-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the nucleotide sequence of a novel cDNA and TNF-induced expression of the corresponding message (mRNA) in human fibroblast cells. This message is also expressed in certain human tumor cell lines and is over-expressed in a colon cancer cell line (HT-29). NIH3T3 cells transfected with the antisense construct of the 5'-region of this novel cDNA formed 20-fold more colonies in culture compared to cells transfected with a sense construct of the same region or the sense and the antisense constructs of the central region of this cDNA. This observation suggests a possible growth suppressor function for the gene represented by this cDNA. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：433 / 439

页数：7

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