Hypochlorous acid and its pharmacological antagonism: An update picture

被引：70

作者：

Lapenna, D

Cuccurullo, F

机构：

[1] Istituto di Fisiopatologia Medica, Universita degli Studi G. D'Annunzio, Facolta di Medicina E Chirurgia, 66100 Chieti, Via Dei Vestini

来源：

GENERAL PHARMACOLOGY | 1996年 / 27卷 / 07期

关键词：

hypochlorous acid; monochloramine; antioxidant; scavenger; oxidative damage; neutrophils;

D O I：

10.1016/S0306-3623(96)00063-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Some biochemical and pathophysiological aspects of hypochlorous acid (a major oxidant species produced by activated white blood cells) are discussed. 2. Moreover, we have discussed the problem of the pharmacological scavenging of hypochlorous acid, focusing attention on the biochemical tests able to study therapeutically relevant scavenging properties of various drugs against hypochlorous acid itself. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：1145 / 1147

页数：3

共 30 条

[1] EVALUATION OF THE ABILITY OF THE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR CAPTOPRIL TO SCAVENGE REACTIVE OXYGEN SPECIES [J].

ARUOMA, OI ;

AKANMU, D ;

CECCHINI, R ;

HALLIWELL, B .

CHEMICO-BIOLOGICAL INTERACTIONS, 1991, 77 (03) :303-314

[2] ACTION OF HYPOCHLOROUS ACID ON THE ANTIOXIDANT PROTECTIVE ENZYMES SUPEROXIDE-DISMUTASE, CATALASE AND GLUTATHIONE-PEROXIDASE [J].

ARUOMA, OI ;

HALLIWELL, B .

BIOCHEMICAL JOURNAL, 1987, 248 (03) :973-976

[3] FREE HYDROXYL RADICALS ARE FORMED ON REACTION BETWEEN THE NEUTROPHIL-DERIVED SPECIES SUPEROXIDE ANION AND HYPOCHLOROUS ACID [J].

CANDEIAS, LP ;

PATEL, KB ;

STRATFORD, MRL ;

WARDMAN, P .

FEBS LETTERS, 1993, 333 (1-2) :151-153

[4] MYELOPEROXIDASE, A CATALYST FOR LIPOPROTEIN OXIDATION, IS EXPRESSED IN HUMAN ATHEROSCLEROTIC LESIONS [J].

DAUGHERTY, A ;

DUNN, JL ;

RATERI, DL ;

HEINECKE, JW .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :437-444

[5] MECHANISM OF HELICOBACTER-PYLORI-ASSOCIATED GASTRIC-MUCOSAL INJURY [J].

DEKIGAI, H ;

MURAKAMI, M ;

KITA, T .

DIGESTIVE DISEASES AND SCIENCES, 1995, 40 (06) :1332-1339

[6]

EATON JW, 1993, J LAB CLIN MED, V1211, P197

[7]

Gutteridge J. M. C., 1989, FREE RADICALS BIOL M

[8] ANTIOXIDANT CHARACTERIZATION - METHODOLOGY AND MECHANISM [J].

HALLIWELL, B .

BIOCHEMICAL PHARMACOLOGY, 1995, 49 (10) :1341-1348

[9] MYELOPEROXIDASE AND SINGLET OXYGEN - REAPPRAISAL [J].

HARRISON, JE ;

WATSON, BD ;

SCHULTZ, J .

FEBS LETTERS, 1978, 92 (02) :327-332

[10] OXIDATION OF LOW-DENSITY-LIPOPROTEIN WITH HYPOCHLORITE CAUSES TRANSFORMATION OF THE LIPOPROTEIN INTO A HIGH-UPTAKE FORM FOR MACROPHAGES [J].

HAZELL, LJ ;

STOCKER, R .

BIOCHEMICAL JOURNAL, 1993, 290 :165-172

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