The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro

被引：14

作者：

Hawser, S ^{[1
]}

Francolini, M ^{[1
]}

Islam, K ^{[1
]}

机构：

[1] UNIV MILAN,DEPT BIOL,I-20133 MILAN,ITALY

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 38卷 / 04期

关键词：

D O I：

10.1093/jac/38.4.579

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (>100 x MIC).

引用

页码：579 / 587

页数：9

共 15 条

[1]

[Anonymous], 1992, M27P NCCLS

[2]

COMPARATIVE-STUDY OF BROTH MACRODILUTION AND MICRODILUTION TECHNIQUES FOR IN-VITRO ANTIFUNGAL SUSCEPTIBILITY TESTING OF YEASTS BY USING THE NATIONAL-COMMITTEE-FOR-CLINICAL-LABORATORY-STANDARDS PROPOSED STANDARD [J].