Insulin-like growth factor-I and estrogen interactions in breast cancer

被引：38

作者：

Martin, MB ^{[1
]}

Stoica, A ^{[1
]}

机构：

[1] Georgetown Univ, Dept Oncol, Vincent T Lombardi Canc Ctr, Washington, DC 20057 USA

来源：

JOURNAL OF NUTRITION | 2002年 / 132卷 / 12期

关键词：

insulin-like growth factor-I; estradiol; estrogen receptor;

D O I：

10.1093/jn/132.12.3799S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

There is increasing evidence that estradiol and insulin-like growth factor-I (IGF-I) act through a complex cross-talk mechanism to stimulate the proliferation of normal mammary epithelium to increase the risk of breast cancer. The emerging model of cross-talk suggests that estradiol regulates the expression of IGF-I and the IGF receptor I. The subsequent binding of IGF-I to its receptor initiates an intracellular signal transduction pathway that activates transcription factors, including the estrogen receptor. Recent studies show that the effects of IGF-I on estrogen receptor activity are mediated in part by the protein kinase A and phosphatidylinositol-3-kinase/Akt pathways.

引用

页码：3799S / 3801S

页数：3

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