Tendon and ligament engineering:: from cell biology to in vivo application

被引：58

作者：

Hoffmann, Andrea ^{[1
]}

Gross, Gerhard ^{[1
]}

机构：

[1] German Res Ctr Biotechnol GBF, D-38124 Braunschweig, Germany

来源：

REGENERATIVE MEDICINE | 2006年 / 1卷 / 04期

关键词：

gene therapy; ligament; regenerative therapy; tendon; tissue engineering;

D O I：

10.2217/17460751.1.4.563

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. in this review, recent work on tendon and ligament development and the use of growth factors for successful cellular therapy of tendon and ligament disorders are discussed. in addition, anti-inflammatory concepts for the treatment of tendon and ligament injuries and recent developments in stem cell engineering for tendon and ligament tissues are examined. Lastly, gene transfer strategies for therapeutic applications to heal tendon and ligament disorders are reviewed.

引用

页码：563 / 574

页数：12

共 95 条

[1]

Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5 [J].

Akiyama, H ;

Shigeno, C ;

Hiraki, Y ;

Shukunami, C ;

Kohno, H ;

Akagi, M ;

Konishi, J ;

Nakamura, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (01) :142-147

[2]

Autologous mesenchymal stem cell-mediated repair of tendon [J].

Awad, HA ;

Butler, DL ;

Boivin, GP ;

Smith, FNL ;

Malaviya, P ;

Huibregtse, B ;

Caplan, AI .

TISSUE ENGINEERING, 1999, 5 (03) :267-277

[3]

Repair of patellar tendon injuries using a cell-collagen composite [J].

Awad, HA ;

Boivin, GP ;

Dressler, MR ;

Smith, FNL ;

Young, RG ;

Butler, DL .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2003, 21 (03) :420-431

[4]

Awad HA, 2000, J BIOMED MATER RES, V51, P233, DOI 10.1002/(SICI)1097-4636(200008)51:2<233::AID-JBM12>3.0.CO

[5]

2-B

[6]

Banes A. J., 1993, PHYSICAL FORCES MAMM, P81

[7]

Influence of dosage and timing of application of platelet-derived growth factor on early healing of the rat medial collateral Ligament [J].

Batten, ML ;

Hansen, JC ;

Dahners, LE .

JOURNAL OF ORTHOPAEDIC RESEARCH, 1996, 14 (05) :736-741

[8]

Fibrocartilage in tendons and ligaments - an adaptation to compressive load [J].

Benjamin, M ;

Ralphs, JR .

JOURNAL OF ANATOMY, 1998, 193 :481-494

[9]

The skeletal attachment of tendons - tendon 'entheses' [J].

Benjamin, M ;

Kumai, T ;

Milz, S ;

Boszczyk, BM ;

Boszczyk, AA ;

Ralphs, JR .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY, 2002, 133 (04) :931-945

[10]

Birk DE, 1997, DEV DYNAM, V208, P291

← 1 2 3 4 5 6 7 8 9 10 →