Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

被引：113

作者：

Hidalgo, E

Ding, HG

Demple, B

机构：

[1] Dept. of Molec. and Cell. Toxicology, Harvard School of Public Health, Boston, MA 02115

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(97)01068-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.

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页码：207 / 210

页数：4

相关论文

共 37 条

[1] ALLOSTERIC UNDERWINDING OF DNA IS A CRITICAL STEP IN POSITIVE CONTROL OF TRANSCRIPTION BY HG-MERR [J].

ANSARI, AZ ;

CHAEL, ML ;

OHALLORAN, TV .

NATURE, 1992, 355 (6355) :87-89

[2] Redox control of gene expression involving iron-sulfur proteins. Change of oxidation-state or assembly disassembly of Fe-S clusters? [J].

Beinert, H ;

Kiley, P .

FEBS LETTERS, 1996, 382 (1-2) :218-219

[3] REGULATION OF BACTERIAL OXIDATIVE STRESS GENES [J].

DEMPLE, B .

ANNUAL REVIEW OF GENETICS, 1991, 25 :315-337

[4] Glutathione-mediated destabilization in vitro of [2Fe-2S] centers in the SoxR regulatory protein [J].

Ding, HE ;

Demple, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9449-9453

[5] The redox state of the [2Fe-2S] clusters in SoxR protein regulates its activity as a transcription factor [J].

Ding, HG ;

Hidalgo, E ;

Demple, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (52) :33173-33175

[6]

FLINT DH, 1993, J BIOL CHEM, V268, P25547

[7]

GARDNER PR, 1991, J BIOL CHEM, V266, P19328

[8] SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form [J].

Gaudu, P ;

Weiss, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10094-10098

[9] Regulation of the soxRS oxidative stress regulon - Reversible oxidation of the Fe-S centers of SoxR in vivo [J].

Gaudu, P ;

Moon, N ;

Weiss, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) :5082-5086

[10] CRYSTALLOGRAPHIC STRUCTURE OF THE NITROGENASE IRON PROTEIN FROM AZOTOBACTER-VINELANDII [J].

GEORGIADIS, MM ;

KOMIYA, H ;

CHAKRABARTI, P ;

WOO, D ;

KORNUC, JJ ;

REES, DC .

SCIENCE, 1992, 257 (5077) :1653-1659

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