Coumarins from Cnidium monnieri and their antiosteoporotic activity

被引：149

作者：

Zhang, Qiaoyan

Qin, Luping ^{[1
]}

He, Weidong

Van Puyvelde, Luc

Maes, Dominick

Adams, An

Zheng, Hanchen

De Kimpe, Norbert

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[2] Univ Ghent, Fac Biosci Engn, Dept Organ Chem, B-9000 Ghent, Belgium

来源：

PLANTA MEDICA | 2007年 / 73卷 / 01期

关键词：

Cnidium monnieri (L.) Cusson; Apiaceae; antiosteoporotic activity; osthole; imperatorin; bergapten; osteoblast; osteoclast;

D O I：

10.1055/s-2006-951724

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bioactivity-guided fractionation has led to the successful isolation of antiosteoporotic components, i.e., osthole, imperatorin and bergapten from an ethanolic extract of the fruits of Cnidium monnieri (L.) Cusson. Among them, osthole was determined as the major compound possessing antiosteoporotic activity. Further study showed that osthole not only promoted the proliferation and activity of alkaline phosphatase of osteoblasts in neonatal calvaria cultures, but also inhibited the bone resorption by decreasing the formation, differentiation and TRAP activity of osteoblasts derived from rat marrow cells.

引用

页码：13 / 19

页数：7

共 24 条

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