Inflammatory bowel disease: a complex group of genetic disorders

被引：32

作者：

Hugot, JP ^{[1
]}

机构：

[1] Hop Robert Debre, INSERM, U458, Dept Paediat Gastroenterol & Nutr,Programme Aveni, F-75019 Paris, France

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2004年 / 18卷 / 03期

关键词：

complex genetic disorder; Inflammatory Bowel Disease; Crohn disease; ulcerative colitis; risk factors; host-bacteria interaction; model of inheritance;

D O I：

10.1016/j.bpg.2004.01.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) are complex genetic disorders resulting from the complex interplay between several genetic and environmental risk factors. The number of IBD genes is currently unknown but it is expected to be equal or higher to 8. None of these genes are expected to be neither necessary nor sufficient for disease development. Among the candidate genes investigated to date, only CARD 15/NOD2 has been definitively associated with Crohn Disease (CD) but not Ulcerative Colitis (UC). This gene explains about 20% of the genetic predisposition to CD. Because it is involved in the innate immunity, it allows to speculate that CD is the result of a defect in host-bacteria interaction. However, it is not known if CD is caused by specific bacteria or the gut flora as a whole.

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页码：451 / 462

页数：12

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