Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis

被引：106

作者：

Bustamante, Alejandro ^{[1
,2
]}

Sobrino, Tomas ^{[3
]}

Giralt, Dolors ^{[1
]}

Garcia-Berrocoso, Teresa ^{[1
]}

Llombart, Victor ^{[1
]}

Ugarriza, Iratxe ^{[4
]}

Espadaler, Marc ^{[1
]}

Rodriguez, Noelia ^{[2
]}

Sudlow, Cathie ^{[5
]}

Castellanos, Mar ^{[6
]}

Smith, Craig J. ^{[7
]}

Rodriguez-Yanez, Manuel ^{[3
]}

Waje-Andreassen, Ulrike ^{[8
]}

Tanne, David ^{[9
,10
]}

Oto, Jun ^{[11
]}

Barber, Mark ^{[12
]}

Worthmann, Hans ^{[13
]}

Wartenberg, Katja E. ^{[14
]}

Becker, Kyra J. ^{[15
]}

Chakraborty, Baidarbhi ^{[16
]}

Oh, Seung-Hun ^{[17
]}

Whiteley, William N. ^{[5
]}

Castillo, Jose ^{[3
]}

Montaner, Joan ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Vall dHebron Inst Res, Neurovasc Res Lab, E-08193 Barcelona, Spain

[2] Hosp Valle De Hebron, Dept Neurol, Barcelona, Spain

[3] Univ Santiago de Compostela, Hlth Res Inst Santiago de Compostela IDIS, Univ Clin Hosp, Dept Neurol,Clin Neurosci Res Lab, Santiago De Compostela, Spain

[4] Hosp Cruces, Dept Neurol, Bilbao, Spain

[5] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH8 9YL, Midlothian, Scotland

[6] Hosp Univ Dr Josep Trueta Girona, Dept Neurol, Biomed Res Inst Girona, Girona, Spain

[7] Univ Manchester, Stroke & Vasc Res Ctr, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Manchester M13 9PL, Lancs, England

[8] Haukeland Hosp, Dept Neurol, Bergen, Norway

[9] Chaim Sheba Med Ctr, Sagol Neurosci Ctr, Tel Aviv, Israel

[10] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[11] Univ Tokushima, Grad Sch, Tokushima, Japan

[12] NHS Lanarkshire, Stroke Managed Clin Network, Nashville, TN USA

[13] Hannover Med Sch, Dept Neurol, Hannover, Germany

[14] Univ Halle Wittenberg, Dept Neurol, Halle, Germany

[15] Univ Washington, Sch Med, Dept Neurol & Neurol Surg, Seattle, WA USA

[16] Dr DY Patil Med Coll, Dept Biochem, Bombay, Maharashtra, India

[17] CHA Univ, CHA Bundang Med Ctr, Dept Neurol, Songnam, South Korea

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 274卷 / 1-2期

关键词：

Stroke; Interleukin-6; Outcome; Meta-analysis; Post-stroke infection; Individual participant data analysis; NECROSIS-FACTOR-ALPHA; BRAIN-DAMAGE; BIOMARKERS; INFLAMMATION; MORTALITY; MARKERS; ASSOCIATIONS; SEVERITY; CYTOKINE; PROFILE;

D O I：

10.1016/j.jneuroim.2014.07.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We aimed to quantify the association of blood interleuldn-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR = 2.346 (1.814-3.033), p <0.0001). However, the additional predictive value of IL-6 was moderate (IDI = 1.5%, NRI = 5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：215 / 224

页数：10

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